Intraflagellar transport complex structure and cargo interactions
نویسندگان
چکیده
منابع مشابه
Intraflagellar transport (IFT) cargo
Intraflagellar transport (IFT) is the bidirectional movement of multisubunit protein particles along axonemal microtubules and is required for assembly and maintenance of eukaryotic flagella and cilia. One posited role of IFT is to transport flagellar precursors to the flagellar tip for assembly. Here, we examine radial spokes, axonemal subunits consisting of 22 polypeptides, as potential cargo...
متن کاملUnderstanding cargo specificity in intraflagellar transport.
Cilia biogenesis and maintenance depends on intraflagellar transport (IFT) that at the same time mediates shuttling of cell-type-specific cargo. Mechanistic understanding of how the general IFT transport machinery links to the movement of specific ciliary cargo remains sparse. In this issue of The EMBO Journal, Zhao and Malicki (2011) show that two components of the IFT machinery (Fleer and IFT...
متن کاملIFT57 stabilizes the assembled intraflagellar transport complex and mediates transport of motility-related flagellar cargo.
Intraflagellar transport (IFT) is essential for the assembly and maintenance of flagella and cilia. Recent biochemical studies have shown that IFT complex B (IFT-B) is comprised of two subcomplexes, IFT-B1 and IFT-B2. The IFT-B2 subunit IFT57 lies at the interface between IFT-B1 and IFT-B2. Here, using a Chlamydomonasreinhardtii mutant for IFT57, we tested whether IFT57 is required for IFT-B co...
متن کاملCrystal structure of the intraflagellar transport complex 25/27.
The cilium is an important organelle that is found on many eukaryotic cells, where it serves essential functions in motility, sensory reception and signalling. Intraflagellar transport (IFT) is a vital process for the formation and maintenance of cilia. We have determined the crystal structure of Chlamydomonas reinhardtii IFT25/27, an IFT sub-complex, at 2.6 Å resolution. IFT25 and IFT27 intera...
متن کاملIntraflagellar transport.
It has been a decade since a novel form of microtubule (MT)-based motility, i.e., intraflagellar transport (IFT), was discovered in Chlamydomonas flagella. Subsequent research has supported the hypothesis that IFT is required for the assembly and maintenance of all cilia and flagella and that its underlying mechanism involves the transport of nonmembrane-bound macromolecular protein complexes (...
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ژورنال
عنوان ژورنال: Cilia
سال: 2013
ISSN: 2046-2530
DOI: 10.1186/2046-2530-2-10